Nitrofurantoin-induced microangiopathic haemolytic anaemia and thrombocytopaenia in a patient with systemic lupus erythematosus
Identifieur interne : 001315 ( Main/Exploration ); précédent : 001314; suivant : 001316Nitrofurantoin-induced microangiopathic haemolytic anaemia and thrombocytopaenia in a patient with systemic lupus erythematosus
Auteurs : Linnette L Pez-L Pez [Porto Rico] ; Noridza Rivera-Rodríguez [Porto Rico] ; Luis M. Vilá [Porto Rico]Source :
- BMJ Case Reports [ 1757-790X ] ; 2012.
English descriptors
- Teeft :
- Adverse drug reactions, Adverse effects, Anaemia, Antibiotic, Antinuclear antibodies, Arthritis rheum, Autoimmune, Autoimmune hepatitis, Case reports, Characterised, Clin pathol, Clinical features, Clinical manifestations, Complement levels, Consecutive days, Disease activity, Drug exposure, Entities share, Erythematosus, Erythrocyte sedimentation rate, Further permission, Glucocorticoid, Haemolytic, Hispanic woman, Lupus, Lymphocyte count, Maha, Microangiopathic, Microangiopathic haemolytic anaemia, Nitrofurantoin, Nitrofurantoin treatment, Normal range, Other hand, Plasma exchange, Plasmapheresis, Platelet, Platelet count, Puerto rico, Pulse glucocorticoid, Pulse glucocorticoid therapy, Purpura, Rheum, Sciences campus, Semin arthriris rheum, Several drugs, Severe thrombocytopaenia, Systemic, Systemic lupus erythematosus, Thrombocytopaenia, Thrombocytopenic, Thrombotic, Thrombotic microangiopathic, Thrombotic microangiopathies, Thrombotic thrombocytopaenic purpura, Thrombotic thrombocytopenia purpura, Thrombotic thrombocytopenic purpura, Urinary tract infections, White blood cell count.
Abstract
Patients with systemic lupus erythematosus (SLE) may develop thrombotic thrombocytopaenic purpura (TTP) or TTP-like illness manifested by microangiopathic haemolytic anaemia (MAHA) and thrombocytopaenia. The distinction between active SLE and TTP is difficult because these entities share similar clinical features. Drug-induced TTP caused by an immune-mediated reaction have been documented for several drugs. Herein, we report a middle-aged Hispanic woman with long-standing SLE, who developed a TTP-like illness characterised by MAHA and thrombocytopaenia after exposure to nitrofurantoin. The patient responded well to plasmapheresis and immunosuppressive therapy and has remained clinically stable after 18 months of follow-up. To our knowledge, this is the first case that reports the association between nitrofurantoin and a TTP-like presentation.
Url:
DOI: 10.1136/bcr-2012-006507
Affiliations:
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The distinction between active SLE and TTP is difficult because these entities share similar clinical features. Drug-induced TTP caused by an immune-mediated reaction have been documented for several drugs. Herein, we report a middle-aged Hispanic woman with long-standing SLE, who developed a TTP-like illness characterised by MAHA and thrombocytopaenia after exposure to nitrofurantoin. The patient responded well to plasmapheresis and immunosuppressive therapy and has remained clinically stable after 18 months of follow-up. To our knowledge, this is the first case that reports the association between nitrofurantoin and a TTP-like presentation.</div></front></TEI><affiliations><list><country><li>Porto Rico</li></country></list><tree><country name="Porto Rico"><noRegion><name sortKey="L Pez L Pez, Linnette" sort="L Pez L Pez, Linnette" uniqKey="L Pez L Pez L" first="Linnette" last="L Pez-L Pez">Linnette L Pez-L Pez</name></noRegion><name sortKey="Rivera Rodriguez, Noridza" sort="Rivera Rodriguez, Noridza" uniqKey="Rivera Rodriguez N" first="Noridza" last="Rivera-Rodríguez">Noridza Rivera-Rodríguez</name><name sortKey="Vila, Luis M" sort="Vila, Luis M" uniqKey="Vila L" first="Luis M" last="Vilá">Luis M. Vilá</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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